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Spectrophotometric Determination of Metoclopramide Hydrochloride in Bulk and Pharmaceutical Preparations by Diazotization-coupling Reaction
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jawad, Aymen Abdulrasool Kadhim, Kasim Hassan |
| Copyright Year | 2013 |
| Abstract | Objective: Develop a simple, rapid, sensitive, selective, and accurate method for the spectrophotometric determination of metoclopramide hydrochloride (MCP-HCl) in bulk and dosage forms. Methods: The method is based on diazotization of primary amine group of (MCP-HCl) with sodium nitrite and hydrochloric acid followed by coupling with 2,5-dimethoxyaniline (DMA) in aqueous mildly acidic medium to form a stable orange azo dye, showed a maximum absorption at 486 nm. Results: Beer's law was obeyed over the concentration range of 0.1-12 ppm with a molar absorptivity 4.55×104 L.mol-1.cm-1. Sandell’s sensitivity, limit of detection (LOD), and limit of quantification (LOQ) are 0.008 μg.cm-2, 0.016 ppm, and 0.054 ppm respectively, the recoveries range 99.15100.80%. Conclusions: The method has been successfully applied to the determination of (MCP-HCl) in its pharmaceutical preparations tablet, syrup, injection and drop with very good recoveries. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ijppsjournal.com/Vol5Suppl3/7310.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
