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Estudio experimental de propiedades viscoelásticas en membranas de liposomas mediante relaxometría magnética nuclear con ciclado rápido de campo magnético
| Content Provider | Semantic Scholar |
|---|---|
| Author | Perlo, Josefina |
| Copyright Year | 2011 |
| Abstract | Lipids dynamics in biological membranes has been of enormous interest to the scienti c community for many years. The viscoelastic and hydrodynamic properties of the membranes are crucial for their function as a selective permeability barrier. Some biomedical applications of liposomes depend critically on microscopic molecular interactions within the membranes, which determine properties such as deformability, permeability, vesicle size and stability. These systems and biological membranes in general have been studied extensively in the last three decades, both structure and dynamics, using a variety of experimental techniques. However, a little progress has been done in the use of eld-cycled relaxometry (also known as fast eld cycling or FFC) for the study of dynamics in membranes. Until the beginning of this work, a systematic study of unilamellar systems was lacking. In this thesis we study the molecular dynamics and viscoelastic properties in lipid membranes of liposomes using the FFC relaxometry technique. The FFC-NMR technique proved to be a useful tool for the study and characterization of the molecular dynamics in liposomes containing di erent lipids, of di erent sizes, at di erent temperatures and di erent contents of cholesterol. Relaxation data of H were interpreted in terms of dynamic processes and their corresponding models successfully used to interpret relaxation dispersions in DMPC and DOPC liposomes: order uctuations, translational di usion over a curved surface, rotational di usion and fast motions. These results were applied to the determination of the elastic properties of membranes. The obtained results suggest that the di usion coe cient tends to increase with the diameter of the liposome and temperature, while rotational correlation time decreases with temperature. The elastic bending constant decreases with increasing temperature and increases with the cholesterol content. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://rdu.unc.edu.ar/bitstream/handle/11086/148/DFis144.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
