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Optimization of the Pharmaceutical Products and Process Design Applying Taguchi Quality Engineering Principles
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ghica, Mihaela Violeta Leca, Minodora Lupuliasa, Dumitru Davila, Carol |
| Copyright Year | 2011 |
| Abstract | The main purpose of Taguchi’s methodology is the optimization of pharmaceutical products quality and the design of the processes in order to become insensitive to the noise sources without their elimination. Analyzing the controlled factors (key factors) by selecting their best variation levels the desired responses, robust to the noise factors variation, are obtained with minimum quality losses. Mathematically, the noise impact on the targeted characteristics is evaluated by the signal/noise ratio. It represents an indicator of the performance characteristics of the pharmaceutical products/processes both from the localization and dispersion point of view. Using Taguchi’s technique supplemented with the response surfaces methodology optimal responses are obtained, the robustness of the products/processes is ensured, time is saved, experimental costs are reduced, in one word the global performance is increased. Rezumat Principalul scop al metodologiei Taguchi este optimizarea calităţii produselor farmaceutice si proiectarea proceselor astfel incât acestea să devină insensibile la diversele surse de zgomot fără a le elimina pe acestea din urmă. Analizarea factorilor controlabili (factori cheie) prin alegerea celor mai bune nivele de variaţie ale acestora conduce la răspunsurile dorite, robuste la modificarea variabilelor de zgomot, cu pierderi minime de calitate. Impactul zgomotelor asupra caracteristicilor urmărite se evaluează din punct de vedere matematic prin raportul semnal/zgomot. Acesta reprezintă un indicator al caracteristicilor de performanţă a produselor/proceselor farmaceutice atât sub aspectul localizării cât si al dispersiei. Prin utilizarea tehnicii Taguchi completată cu metodologia suprafeţelor de răspuns se obţin rezultate optime, se asigură robusteţea produselor/proceselor, se economiseste timp, se reduc costurile experimentale, intr-un cuvânt creste performanţa globală. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.revistafarmacia.ro/20113/art3.ghica.farmacia3.2011.321-328.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
