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Improvement of extrapyramidal symptoms following dehydroepiandrosterone (DHEA) administration in antipsychotic treated schizophrenia patients: A randomized, double-blind placebo controlled trial
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nachshoni, Tali Ebert, Tanya Abramovitch, Yehuda Assael-Amir, Miriam Strous, Rael D. |
| Copyright Year | 2005 |
| Abstract | Recent investigation in schizophrenia indicated dehydroepiandrosterone (DHEA) levels to be inversely correlated with extrapyramidal symptomatology (EPS). This study thus investigates the effect of DHEA administration on medication-induced EPS. Inpatients with schizophrenia or schizoaffective disorder were randomized in double-blind fashion to receive either 100 mg DHEA or placebo in addition to a constant dosage of antipsychotic medication. Parkinsonism showed a favorable effect of DHEA with a significant time effect (p < 0.0001), as well as a significant group by time interaction (p < 0.05) and with no change noted on akathisia. Change of DHEA blood levels was negatively associated with change of Parkinsonism (p < 0.05) as well as with change of total EPS ratings (p < 0.05). DHEA appears to demonstrate a significant effect on EPS, with improvement observed particularly in Parkinsonian symptoms. |
| Starting Page | 251 |
| Ending Page | 256 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.schres.2005.07.029 |
| PubMed reference number | 16126372 |
| Journal | Medline |
| Volume Number | 79 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0920996405002987 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0920996405002987?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.schres.2005.07.029 |
| Journal | Schizophrenia Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
