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Quantitative Estimation of Some Volatile N-Nitrosamines in Tobacco Smoke Using Validated GC-MS Method
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rubashvili, Imeda |
| Copyright Year | 2015 |
| Abstract | The aim of this work was the quantitative estimation of some volatile N-nitrosamines in tobacco smoke of local cigarette different brands using an efficient, rapid and sensitive GC-MS method which was validated before. The chromatographic system suitability was tested by using the following characteristics: The RSD, % of peak areas (five replicate injections) was 2000; the tailing factor 2.0 for all N-nitrosamines. The calibration curve was linear over a concentration range 0.5 - 100 µg mL -1 with a correlation coefficient >0.99. The LOD and LOQ were 0.25 µg mL -1 and 0.5 µg mL -1 , respectively. This method can be used to determine nine volatile N-nitrosamines namely N-nitrosodimethylamine (NDMA), N-nitrosomethylethylamine (NMEA), N-nitrosodiethylamine (NDEA), N-nitrosodipropylamine (NDPA), N-nitrosodibutylamine (NDBA), N-nitrosopiperidine (NPIP), N-nitrosopyrrolidine (NPYR), N-nitrosomorpholine (NMPA), N-nitrosodiphenylamine (NDPA) diluted in solvent - methanol as a sample solution which can be obtained from tobacco smoke or solid/liquid material using extraction. The determined quantities of some volatile N-nitrosamines - NDMA, NMEA and NDEA in tobacco smoke vary 190 - 320, 87 – 119 and 99 – 166 ng/cigarette, respectively. |
| Starting Page | 79 |
| Ending Page | 91 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.14233/ajchem.2015.18930 |
| Alternate Webpage(s) | http://www.eurasianjournals.com/pdf-78303-14336?filename=Quantitative+Estimation.pdf |
| Alternate Webpage(s) | https://doi.org/10.14233/ajchem.2015.18930 |
| Volume Number | 9 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
