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Evaluación del efecto antioxidante e hipoglicemiante del extracto hidroalcohólico de la corteza de Curarea tecunarum “abuta” en ratones albinos con hiperglicemia inducida por aloxano
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cáceres, Camila Maritza Espíndola Choque, Johanna Carolina Chambi |
| Copyright Year | 2018 |
| Abstract | The present work research is an experimental, prospective and longitudinal study, whose objective is to determine the hypoglycemic and antioxidant effect of the hydroalcoholic extract of the bark of Curarea tecunarum "abuta". The study was carried out with 30 female Balb C57 albino mice, with an average weight of 30 ± 5 g, to which hyperglycemia was induced by intraperitoneal administration of alloxan by the modified Mendez method.1,2 Subsequently they were administered the hydroalcoholic extract of bark of Curarea tecunarum, at a dose of 30 mg/kg, 50 mg/kg and 100 mg / kg and the hypoglycemic effect was compared with the standard drug glibenclamide 10 mg/Kg . The study determined that there is a significant difference between the three treatments of 100 mg/Kg, 50 mg/Kg and 30 mg/Kg of hydroalcoholic extract of Curarea tecunarum, also showed that the dose of 100 mg/Kg of extract exceeds the hypoglycemic effect of glibenclamide. The antioxidant activity was determined in the concentrations of 300 ppm and 600 ppm of the hydroalcoholic extract of the bark of Curarea tecunarum by the Brand-Williams method (DPPH), comparing the antioxidant activity of "abuta" against vitamin C, obtaining as a result 96% of antioxidant activity. The medicinal properties of "abuta" were corroborated as traditional use for the treatment of diabetes, having a hypoglycemic and antioxidant effect. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cybertesis.unmsm.edu.pe/xmlui/bitstream/handle/cybertesis/7899/Espindola_cc.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
