NDLI: LGALS3BP, lectin galactoside-binding soluble 3 binding protein, induces vascular endothelial growth factor in human breast cancer cells and promotes angiogenesis

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LGALS3BP, lectin galactoside-binding soluble 3 binding protein, induces vascular endothelial growth factor in human breast cancer cells and promotes angiogenesis

Content Provider	Semantic Scholar
Author	Piccolo, Enza Tinari, Nicola Semeraro, Daniela Traini, Sara Fichera, Imma Cumashi, Albana Sorda, Rossana La Spinella, Francesca M. Bagnato, Anna Lattanzio, Rossano Egidio, Maurizia D’ Risio, Annalisa Di Stampolidis, Pavlos Piantelli, Mauro Natoli, Clara Ullrich, Axel Iacobelli, Stefano
Copyright Year	2012
Abstract	Elevated serum or tissue levels of lectin galactoside-binding soluble 3 binding protein (LGALS3BP) have been associated with short survival and development of metastasis in a variety of human cancers. However, the role of LGALS3BP, particularly in the context of tumor–host relationships, is still missing. Here, we show that LGALS3BP knockdown in MDA-MB-231 human breast cancer cells leads to a decreased adhesion to fibronectin, a reduced transendothelial migration and, more importantly, a reduced expression of vascular endothelial growth factor (VEGF). Production of VEGF, that was restored by exposure of silenced cells to recombinant LGALS3BP, required an intact PI3k/Akt signaling. Furthermore, we show that LGALS3BP was able to directly stimulate HUVEC tubulogenesis in a VEGF-independent, galectin-3-dependent manner. Immunohistochemical analysis of human breast cancer tissues revealed a correlation among LGALS3BP expression, VEGF expression, and blood vessel density. We propose that in addition to its prometastatic role, LGALS3BP secreted by breast cancer cells functions critically as a pro-angiogenic factor through a dual mechanism, i.e by induction of tumor VEGF and stimulation of endothelial cell tubulogenesis.
Starting Page	83
Ending Page	94
Page Count	12
File Format	PDF HTM / HTML
DOI	10.1007/s00109-012-0936-6
PubMed reference number	22864925
Journal	Medline
Volume Number	91
Alternate Webpage(s)	http://www.mediapharma.it/wp-content/uploads/2013/11/Piccolo-E-JMOL-MED.pdf
Alternate Webpage(s)	https://doi.org/10.1007/s00109-012-0936-6
Journal	Journal of Molecular Medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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