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Examination of synovial fluid and serum hyaluronidase activity as a joint marker in rheumatoid arthritis and osteoarthritis patients (by zymography).
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nagaya, Hiroshi Ymagata, T. Ymagata, S. Iyoda, Kenya Ito, Hideto Hasegawa, Yukiharu Iwata, Hiroka |
| Copyright Year | 1999 |
| Abstract | OBJECTIVE Hyaluronic acid (HA) is an important joint marker and the substrate for hyaluronidase (HAase). Synovial fluid (SF) and serum HAase were measured to investigate the potential use of HAase as a joint marker in rheumatoid arthritis (RA) and osteoarthritis (OA) patients. METHODS The subjects were 39 patients with RA and 42 patients with OA. HAase activity was measured by zymography and its relation with various parameters examined statistically. RESULTS In RA SF a positive correlation (r = 0.458, p = 0.0186) was found between SF HAase activity and the concentration of serum C reactive protein. A positive correlation (r = 0.45, p = 0.024) was also found between SF HAase activity and platelet count in the RA group. Serum HAase activity in the RA group was significantly higher than in the OA group (p < 0.0001) and normal controls (p < 0.0001). CONCLUSION The results suggest that SF HAase activity could be used as a marker of synovial inflammation. |
| Starting Page | 49 |
| Ending Page | 55 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ard.bmj.com/content/annrheumdis/58/3/186.full.pdf |
| PubMed reference number | 10364918v1 |
| Volume Number | 58 |
| Issue Number | 3 |
| Journal | Annals of the rheumatic diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Blood Platelet Disorders Degenerative polyarthritis Hyaluronic Acid Hyaluronidase Patients Platelet Count measurement Rheumatoid Arthritis Synovial Fluid |
| Content Type | Text |
| Resource Type | Article |
