NDLI: Autoantigen specific IL-2 activated CD4+CD25+T regulatory cells inhibit induction of experimental autoimmune neuritis

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Autoantigen specific IL-2 activated CD4+CD25+T regulatory cells inhibit induction of experimental autoimmune neuritis

Content Provider	Semantic Scholar
Author	Tran, Giang T. Hodgkinson, Suzanne J. Carter, Nicole Verma, Nirupama D. Hall, Bruce M.
Copyright Year	2020
Abstract	Experimental autoimmune neuritis (EAN) induced by peripheral nerve myelin (PNM) is self-limiting and re-immunization with PNM does not re-activate disease. This study showed inhibition of EAN by CD4+CD25+T cells both from sensitized hosts or from naïve hosts after ex-vivo activation by PNM and rIL-2. Transfer of naïve CD4+CD25+T cells has no effect on EAN, nor did naïve CD4+CD25+T cells activated with rIL-2 and renal tubular antigen. Culture of naive CD4+CD25+Treg with rIL-2 and PNM induced mRNA for the IFN-gamma receptor. We showed naïve CD4+CD25+T cells activated by specific auto-antigen and rIL-2 produced more potent antigen-specific Treg that may have therapeutic potential.
File Format	PDF HTM / HTML
DOI	10.1016/j.jneuroim.2020.577186
PubMed reference number	32058174
Journal	Medline
Volume Number	341
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0165572819305363
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0165572819305363?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.jneuroim.2020.577186
Journal	Journal of Neuroimmunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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