NDLI: Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

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Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

Content Provider	Semantic Scholar
Author	Narita, Masashi Nũnez, Sabrina Heard, Edith Narita, Masako Lin, Athena Hearn, Stephen A. Spector, David L. Hannon, Gregory J. Lowe, Scott W.
Copyright Year	2003
Abstract	Cellular senescence is an extremely stable form of cell cycle arrest that limits the proliferation of damaged cells and may act as a natural barrier to cancer progression. In this study, we describe a distinct heterochromatic structure that accumulates in senescent human fibroblasts, which we designated senescence-associated heterochromatic foci (SAHF). SAHF formation coincides with the recruitment of heterochromatin proteins and the retinoblastoma (Rb) tumor suppressor to E2F-responsive promoters and is associated with the stable repression of E2F target genes. Notably, both SAHF formation and the silencing of E2F target genes depend on the integrity of the Rb pathway and do not occur in reversibly arrested cells. These results provide a molecular explanation for the stability of the senescent state, as well as new insights into the action of Rb as a tumor suppressor.
Starting Page	703
Ending Page	716
Page Count	14
File Format	PDF HTM / HTML
DOI	10.1016/S0092-8674(03)00401-X
PubMed reference number	12809602
Journal	Medline
Volume Number	113
Alternate Webpage(s)	http://cancan.cshl.edu/publications/Narita_2003_12809602.pdf
Alternate Webpage(s)	http://codex.cshl.org/publications/Narita_2003_12809602.pdf
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S009286740300401X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S009286740300401X
Alternate Webpage(s)	https://doi.org/10.1016/S0092-8674%2803%2900401-X
Journal	Cell
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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