NDLI: Protective Effects of Aqueous and Ethanolic Extracts of the Leaf of Cassia italica in CCl4-induced Liver Damage in Rats

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Protective Effects of Aqueous and Ethanolic Extracts of the Leaf of Cassia italica in CCl4-induced Liver Damage in Rats

Content Provider	Semantic Scholar
Author	Nadro, M. S. Adama, M. A. Hamma
Copyright Year	2014
Abstract	Renewed attention in recent decades to alternative medicines and natural therapies has stimulated a new wave of research interest in traditional practices. The plant kingdom has become a target for the search for new drugs and biologically active compounds. The present study was designed to evaluate the hepatoprotective effects of aqueous and ethanol extracts of Cassia italica leaves in carbon tetrachloride-induced hepatotoxicity in rats. Histopathology of the liver was also studied in CCl4 induced liver damage in pretreated rats. Pre-treatment with 200mg/kg body weight of Cassia italica leaf extract gave some measure of protection to the rats against CCl4 liver damage. Serum and liver enzymes tested (AST, ALT, ALP and G-GT) were all significantly (p ≤ 0.05) lowered when compared to with the negative control. Total bilirubin was reduced from 2.91 ± 0.03 in experimental control to 1.70 ± 0.06 with ethanol extract and to 1.41 ± 0.15 with aqueous extract. Cholesterol levels were significantly (p ≤ 0.001) lowered from the elevated levels of the untreated group when compared to treated group (244.1 ± 4.76 to 127.2 ± 2.32 and 126.33 ± 2.01 with ethanol and aqueous extracts respectively). Albumin levels significantly (p ≤ 0.05) increased with ethanol extract in serum of treated rats. Lipid peroxidation as assayed by thiobarbituric acid reactive substances was significantly reduced (p ≤ 0.05). Histopathological studies also provided supportive evidence for the biochemical analysis.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.usa-journals.com/wp-content/uploads/2014/05/Nadro_Vol26.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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