NDLI: Coronary dilating effects of intracoronary nicorandil. Comparison with isosorbide dinitrate.

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Coronary dilating effects of intracoronary nicorandil. Comparison with isosorbide dinitrate.

Content Provider	Semantic Scholar
Author	Ejima, Junichi Kaneda, Koh Moriyama, Hirochi Ohmura, I. Maruyama, Toru Kaji, Yoshikazu Tsuda, Yasuo Kanaya, Shozo Fujino, Takehiko Niho, Yoshiyuki
Copyright Year	1995
Abstract	Although nicorandil, N-(2-hydroxyethyl) nicotinamide dinitrate, is a nitrate ester, its cardiovascular action differs from that of nitrate compounds in several aspects. In this quantitative angiographic study, the acute coronary dilating effect of intracoronary nicorandil (0.25, 0.50, 1.0 mg) was compared with that of isosorbide dinitrate (ISDN; 1.0 mg) in 46 patients with or without ischemic heart disease (IHD). Dose-dependent right coronary dilating action was observed by intracoronary administration of nicorandil without any adverse effects. The same degree of right coronary dilation was achieved by the intracoronary application of equivalent doses of ISDN. We conclude that intracoronary administration of nicorandil is beneficial for the supportive treatment of IHD during coronary artery investigation and intervention without the risk of severe systemic hypotension.
Starting Page	699
Ending Page	707
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/ihj1960/36/6/36_6_699/_pdf
PubMed reference number	8627976v1
Volume Number	36
Issue Number	6
Journal	Japanese heart journal
Language	English
Access Restriction	Open
Subject Keyword	Dilate procedure Esters Heart Diseases Isosorbide Dinitrate Myocardial Ischemia Nicorandil Nitrates Patients
Content Type	Text
Resource Type	Article

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