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Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA).
| Content Provider | Semantic Scholar |
|---|---|
| Author | Vihinen, Mauno Mattsson, Pekka Tapani Smith, Charles I. |
| Copyright Year | 2000 |
| Abstract | X-linked agammaglobulinemia (XLA) is a heritable immunodeficiency disorder that is caused by a differentiation block leading to almost complete absence of B lymphocytes and plasma cells. The affected protein is a cytoplasmic protein tyrosine kinase, Bruton's agammaglobulinemia tyrosine kinase (Btk). Btk along with Tec, Itk, Bmx and Txk belong to a distinct family of protein kinases. These proteins contain five regions; PH, TH, SH3, SH2 and kinase domains. Mutations causing XLA may affect any of these domains. About 380 unique mutations have been identified and are collected in a mutation database, BTKbase. Here, we describe the structure, function, and interactions of the affected signaling molecules in atomic detail. |
| File Format | PDF HTM / HTML |
| DOI | 10.2741/vihinen |
| PubMed reference number | 11102316 |
| Journal | Medline |
| Volume Number | 5 |
| Alternate Webpage(s) | https://www.bioscience.org/2000/v5/d/vihinen/vihinen.pdf |
| Alternate Webpage(s) | http://www.bioscience.org/2000/v5/d/vihinen/vihinen.pdf |
| Journal | Frontiers in bioscience : a journal and virtual library |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
