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Estimating a Preference-Based Index for an Eight-Dimensional Health State Classification System for Multiple Sclerosis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Goodwin, Elizabeth Green, Colin Spencer, Anne |
| Copyright Year | 2015 |
| Abstract | BACKGROUND Condition-specific measures are frequently used to assess the health-related quality of life of people with multiple sclerosis (MS). Such measures are unsuitable for use in economic evaluations that require estimates of cost per quality-adjusted life-year because they are not based on preferences. OBJECTIVES To report the estimation of a preference-based single index for an eight-dimensional instrument for MS, the Multiple Sclerosis Impact Scale - Eight Dimensions (MSIS-8D), derived from an MS-specific measure of health-related quality of life, the 29-item Multiple Sclerosis Impact Scale (MSIS-29). METHODS We elicited preferences for a sample of MSIS-8D states (n = 169) from a sample (n = 1702) of the UK general population. Preferences were elicited using the time trade-off technique via an Internet-based survey. We fitted regression models to these data to estimate values for all health states described by the MSIS-8D. Estimated values were assessed against MSIS-29 scores and values derived from generic preference-based measures in a large, representative sample of people with MS. RESULTS Participants reported that the time trade-off questions were easy to understand. Observed health state values ranged from 0.08 to 0.89. The best-performing model was a main effects, random effects model (mean absolute error = 0.04). Validation analyses support the performance of the MSIS-8D index: it correlated more strongly than did generic measures with MSIS-29 scores, and it discriminated effectively between subgroups of people with MS. CONCLUSIONS The MSIS-8D enables health state values to be estimated from the MSIS-29, adding to the methods available to assess health outcomes and to estimate quality-adjusted life-years for MS for use in health technology assessment and decision-making contexts. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.jval.2015.10.004 |
| PubMed reference number | 26686787 |
| Journal | Medline |
| Volume Number | 18 |
| Issue Number | 8 |
| Alternate Webpage(s) | https://ore.exeter.ac.uk/repository/bitstream/handle/10871/20361/Value%20Health%202015%20-%20Goodwin.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.jval.2015.10.004 |
| Journal | Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
