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Cytotoxicity Activity of Biotransformed Ethyl p-methoxycinnamate by Aspergillus niger MUHAMMAD NOR OMAR
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yarmo, Mohd. Ambar |
| Copyright Year | 2016 |
| Abstract | The extraction of Kaempferia galanga rhizome using steam distillation and supercritical fluid extraction (SFE) was carried out. After fractionation, the major compound of the K. galanga extract, ethyl p-methoxycinnamate (EPMC) was transformed using Aspergillus niger into ethyl p-hydroxycinnamate (EPHC). The biological anticancer activity of EPMC and its biotransformed product (EPHC) was established by cytotoxicity activity on the human breast cancer (MCF-7) cell line using MTT assay. Ethyl p-hydroxycinnamate (EPHC) was most cytotoxic against MCF-7 at 1000 μg/mL where percentage of cell viability was 9.87 %, while IC50 was 340 μg/mL. EPHC showed slightly higher cytotoxicity activity compared to EPMC. The results of this study show that the biotransformation process was able to produce a metabolite (EPHC) with higher cytotoxicity activity compared to its parent compound (EPMC). |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.orientjchem.org/download/23625/ |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aspergillus niger Ab.IgE:ACnc:Pt:Ser:Qn Benzocaine Cell Survival Distillation Human Neprilysin Inhibitory Concentration 50 Mammary Neoplasms Metabolic Biotransformation One Thousand Rhizome Secure two-party computation Supercritical Fluid Extraction USB hub Urethane icosapent ethyl monooxyethylene trimethylolpropane tristearate |
| Content Type | Text |
| Resource Type | Article |
