NDLI: Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae.

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Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae.

Content Provider	Semantic Scholar
Author	Degtyareva, Natalya P. Chen, Lingling Mieczkowski, Piotr A. Petes, Thomas D. Doetsch, Paul W.
Copyright Year	2008
Abstract	Oxidative DNA damage is likely to be involved in the etiology of cancer and is thought to accelerate tumorigenesis via increased mutation rates. However, the majority of malignant cells acquire a specific type of genomic instability characterized by large-scale genomic rearrangements, referred to as chromosomal instability (CIN). The molecular mechanisms underlying CIN are not entirely understood. We utilized Saccharomyces cerevisiae as a model system to delineate the relationship between genotoxic stress and CIN. It was found that elevated levels of chronic, unrepaired oxidative DNA damage caused chromosomal aberrations at remarkably high frequencies under both selective and nonselective growth conditions. In this system, exceeding the cellular capacity to appropriately manage oxidative DNA damage resulted in a "gain-of-CIN" phenotype and led to profound karyotypic instability. These results illustrate a novel mechanism for genome destabilization that is likely to be relevant to human carcinogenesis.
Starting Page	75
Ending Page	79
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.603.3872&rep=rep1&type=pdf
PubMed reference number	18591251v1
Alternate Webpage(s)	https://doi.org/10.1128/MCB.00307-08
DOI	10.1128/mcb.00307-08
Journal	Molecular and cellular biology
Volume Number	28
Issue Number	17
Language	English
Access Restriction	Open
Subject Keyword	Carcinogenesis Chromosomal Instability Chromosome Aberrations DNA Damage DNA Repair DNA Sequence Rearrangement Genotoxic Stress Mutation Neoplasms cancer cell
Content Type	Text
Resource Type	Article

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Chronic Oxidative DNA Damage Due to DNA Repair Defects Causes Chromosomal Instability in Saccharomyces cerevisiae ▿ †

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