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2,3-Diphosphoglyceric acid blocks long-term potentiation of excitatory postsynaptic currents in hippocampal CA1 neurons of the rat
| Content Provider | Semantic Scholar |
|---|---|
| Author | Behnisch, Thomas Reymann, Klaus G. |
| Copyright Year | 1994 |
| Abstract | The dependence of long-term potentiation on an intact inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] metabolism was investigated with the whole-cell voltage-clamp method in the CA1 region of hippocampal slices. The intracellular application of 2,3-diphosphoglyceric acid (1 mM), an inhibitor of the Ins(1,4,5)P3 5-phosphatase and of Ins(1,4,5)P3 3-kinase eliminated the potentiation of postsynaptic currents in pyramidal cells 30 min after paired pre- and postsynaptic activation. These data suggest a possible role of postsynaptic inositol 1,4-bisphosphate and/or inositol 1,3,4,5-tetra-kisphosphate in synaptic plasticity. |
| Starting Page | 23 |
| Ending Page | 26 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(94)90700-5 |
| PubMed reference number | 8015732 |
| Journal | Medline |
| Volume Number | 165 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394094907005 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394094907005?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2894%2990700-5 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
