Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis

Content Provider	Semantic Scholar
Author	Mifsud, Jean-Christophe Hernández, Luis Hoebel, Bartley G.
Copyright Year	1989
Abstract	It has been postulated that addiction to nicotine is mediated by dopamine release in the mesolimbic system. It is possible that nicotine might act directly on the dopamine terminals to release dopamine. This hypothesis was tested by infusing nicotine through a microdialysis probe into the nucleus accumbens of freely moving rats. Dopamine, dihydroxyphenylacetic acid, and homovanillic acid from the extracellular space were collected by microdialysis and measured by high pressure liquid chromatography. Nicotine increased extracellular dopamine in a dose-related manner. Systemic injection of the nicotine antagonist mecamylamine blocked the dopamine increase induced by local nicotine. These results suggest that nicotine releases dopamine by a local action in the nucleus accumbens terminal area of the mesolimbic system. Presynaptic induction of dopamine release might play a role in nicotine addiction.
Starting Page	365
Ending Page	367
Page Count	3
File Format	PDF HTM / HTML
DOI	10.1016/0006-8993(89)91518-7
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0006899389915187
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0006899389915187?dgcid=api_sd_search-api-endpoint
PubMed reference number	2924134
Alternate Webpage(s)	https://doi.org/10.1016/0006-8993%2889%2991518-7
Journal	Medline
Volume Number	478
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article