Beyond the increasing complexity of the immunomodulatory HLA-G molecule.

Content Provider	Semantic Scholar
Author	Carosella, Edgardo Delfino Favier, Benoit Rouas-Freiss, Nathalie Moreau, Philippe Lemaoult, Joel
Copyright Year	2008
Abstract	Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex (MHC) class I molecule that functions as an immunomodulatory molecule capable of protecting fetal tissues from the maternal immune system. The relevance of HLA-G in other contexts was investigated soon afterward. Numerous studies have sought (and some have shown) the relevance of HLA-G in pathologic conditions, such as transplantation, autoimmunity, and cancer and hematologic malignancies. One of the main goals of the current research on HLA-G is now to use it in the clinic, either for diagnosis or as a therapeutic tool/target. For this, precise knowledge on the nature and functions of HLA-G is critical. We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant.
Starting Page	623
Ending Page	633
Page Count	11
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/111/10/4862.full.pdf?sso-checked=true
PubMed reference number	18334671v1
Alternate Webpage(s)	https://doi.org/10.1182/blood-2007-12-127662
DOI	10.1182/blood-2007-12-127662
Journal	Blood
Volume Number	111
Issue Number	10
Language	English
Access Restriction	Open
Subject Keyword	Autoimmune Diseases Fetal Tissue HLA Antigens HLA Complex HLA-DQ Antigens Hematologic Neoplasms Hematology (discipline) Histocompatibility Antigens Class II Immune system Leukocytes Major Histocompatibility Complex
Content Type	Text
Resource Type	Article