NDLI: HJURP regulates cellular senescence in human fibroblasts and endothelial cells via a p53-dependent pathway.

Content Provider	Semantic Scholar
Author	Heo, Jong-Ik Cho, Jung Hee Kim, Jae-Ryong
Copyright Year	2013
Abstract	Holliday junction recognition protein (HJURP), a centromere protein-A (CENP-A) histone chaperone, mediates centromere-specific assembly of CENP-A nucleosome, contributing to high-fidelity chromosome segregation during cell division. However, the role of HJURP in cellular senescence of human primary cells remains unclear. We found that the expression levels of HJURP decreased in human dermal fibroblasts and umbilical vein endothelial cells in replicative or premature senescence. Ectopic expression of HJURP in senescent cells partially overcame cell senescence. Conversely, downregulation of HJURP in young cells led to premature senescence. p53 knockdown, but not p16 knockdown, abolished senescence phenotypes caused by HJURP reduction. These data suggest that HJURP plays an important role in the regulation of cellular senescence through a p53-dependent pathway and might contribute to tissue or organismal aging and protection of cellular transformation.
File Format	PDF HTM / HTML
DOI	10.1093/gerona/gls257
PubMed reference number	23292286
Journal	Medline
Volume Number	68
Issue Number	8
Alternate Webpage(s)	https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/biomedgerontology/68/8/10.1093/gerona/gls257/2/gls257.pdf?Expires=1497874818&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=Zwv2UEp19U1yMUo9jDNjFCAjnhBv5TTcrT2M1kCMWoAohlVeyfsl0b5nARHdrUk9GsynRHoEq-SCSNDEROo5JIfU7bglPIK9MpLlTRpo0wpxxgPwvAM2j2c8wxctDiA96wznxaBQOQRgpDsyU4DnFxrEoWWs-qoQy0XSNpEJjHMV6YH9N3JxgG4m8zU5pGpoW2VPfwaTtmB9umRyYpCFGiAqiKAcWutprV4TGk626BeP34Akmlus~gZCwXSMyqVXyil4jXtxn56HZjdC2B4mECFgwQQjjUP9pxKoh-jpiNPTvgyoxMHpViLLKu9nN1eQdFNYCEbTcPu1C~bUW1NOBg__
Alternate Webpage(s)	https://doi.org/10.1093/gerona%2Fgls257
Journal	The journals of gerontology. Series A, Biological sciences and medical sciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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