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Eicosapentaenoic and docosahexaenoic acids increase insulin sensitivity in growing steers.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cartiff, Sydney E. Fellner, Vivek Eisemann, Joan H. |
| Copyright Year | 2013 |
| Abstract | An experiment was conducted to determine the effect of dietary n-3 long chain PUFA on insulin sensitivity in growing steers. Steers (n = 12, initial BW = 336.3 kg, SEM = 7.7) were adapted to a basal diet that was 70% concentrate mix and 30% orchardgrass hay. Steers were fed a daily amount of 0.26 Mcal ME per kg BW (0.75). After 3 wk steers were transitioned to 1 of 2 treatment (Trt) diets (n = 6 per diet) containing added Ca salts of fatty acids at 4% of DM using a source of fat that was enriched in n-3 fatty acids, including eicosapentaenoic acid and docosahexaenoic acid (FOFA), or a source of fat without n-3 fatty acids and a greater percentage of C16:0 and C18:1 (LCFA). Three intravenous (i.v.) glucose tolerance tests (IVGTT) were conducted, 1 during the basal diet, and 2 after transition to treatment diets at time 1 (T1; d 4 Trt) and time 2 (T2; d 39 Trt). Three i.v. insulin challenge tests (IC) were conducted the day after each IVGTT. Measurements on the basal diet were used as covariates. For IVGTT, there was a diet by time interaction (P < 0.05) for glucose area under the response curve (AUC). The AUC50 (mM glucose × 50 min) at T1 was less (P = 0.02) for LCFA (126.2) than FOFA (151.8), AUC50 at T2 tended to be greater (P = 0.07) for LCFA (165.9) than FOFA (146.0). Preinfusion insulin concentration was greater (P < 0.001) before the IVGTT and IC for steers fed LCFA (40.4 and 40.2 µIU/mL) than for steers fed FOFA (23.7 and 27.1 µIU/mL), respectively. Glucose clearance did not differ between treatments. For IC, minimum glucose concentration was greater (P = 0.02) and glucose AUC150 was less (P < 0.01) for steers fed LCFA than for steers fed FOFA. Values for glucose concentration were 1.8 mM and 1.5 mM and for AUC150 (mM glucose × 150 min) were 203.1 and 263.6 for steers fed LCFA and FOFA, respectively. Insulin clearance (fraction/min) was greater (P < 0.01) for steers fed LCFA (0.121) than FOFA (0.101). The insulin AUC60 (µIU/mL × 60 min) postinfusion was less for LCFA (17,674) than FOFA (19,997), and tended to be greater (P = 0.06) at T1 (19,552) than T2 (18,119). Plasma NEFA concentrations at T2 during IVGTT were greater (P < 0.05) in steers fed FOFA than in steers fed LCFA. The results indicated that supplementing with long-chain n-3 PUFA (FOFA) increased insulin sensitivity in growing steers compared with feeding a supplement with greater concentration of SFA (LCFA). |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.animalsciencepublications.org/publications/jas/pdfs/91/5/2332 |
| PubMed reference number | 23463554v1 |
| Alternate Webpage(s) | https://doi.org/10.2527/jas.2012-5694 |
| DOI | 10.2527/jas.2012-5694 |
| Journal | Journal of animal science |
| Volume Number | 91 |
| Issue Number | 5 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Area Under Curve Basal Diet Basal cell carcinoma Dactylis Docosahexaenoic Acids Eicosapentaenoic Acid Fatty acid glycerol esters Glucose Metabolism Disorders Glucose tolerance test Hyperinsulinism Impaired glucose tolerance Insulin Nonesterified Fatty Acids Omega-3 Fatty Acids Platelet Glycoprotein 4, human Polyunsaturated Fatty Acids Salts docosahexaenoic acid insulin, isophane |
| Content Type | Text |
| Resource Type | Article |
