NDLI: Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice.

Content Provider	Semantic Scholar
Author	Dymecki, Susan M.
Copyright Year	1996
Abstract	Site-specific recombinases are being developed as tools for "in vivo" genetic engineering because they can catalyze precise excisions, integrations, inversions, or translocations of DNA between their distinct recognition target sites. Here it is demonstrated that Flp recombinase can effectively mediate site-specific excisional recombination in mouse embryonic stem cells, in differentiating embryonal carcinoma cells, and in transgenic mice. Broad Flp expression is compatible with normal development, suggesting that Flp can be used to catalyze recombination in most cell types. These properties indicate that Flp can be exploited to make prescribed alterations in the mouse genome.
File Format	PDF HTM / HTML
DOI	10.1073/pnas.93.12.6191
PubMed reference number	8650242
Journal	Medline
Volume Number	93
Issue Number	12
Alternate Webpage(s)	http://www.uniroma2.it/didattica/Frezza/deposito/FLP_recomb_PNAS.pdf
Alternate Webpage(s)	https://doi.org/10.1073/pnas.93.12.6191
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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