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Identification of platelet hyper-reactivity measured with a portable device immediately after percutaneous coronary intervention predicts in stent thrombosis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jacopo, Gianetti Elisabetta, Volpi Silverio, Sbrana Massimiliano, Mariani Sergio, Berti Grazia, Andreassi Maria Philippe, Collet Jean |
| Copyright Year | 2007 |
| Abstract | INTRODUCTION Platelet hyper-reactivity, despite a standard anti-thrombotic therapy, is a recognized risk factor for recurrent myocardial ischemia and in-stent thrombosis following PCI. We have investigated whether this detrimental condition, measured by collagen-epinephrine closure times (CEPI-CT) with the Platelet Function Analyzer (PFA-100) device could predict IST defined as the composite of cardiovascular death or myocardial infarction. MATERIALS AND METHODS CEPI-CT was measured in 256 consecutive patients with stable angina (n=103) or ACS (n=153) 30+/-8 h after PCI (T 0) and 1 month later (T1). All patients were followed up for a mean period of 9 months. Platelet hyperactivity was defined as a CEPI-CT<190 s. RESULTS Baseline CEPI-CT<190 s was associated with a higher rate of death or MI (LogRank chi2=4.23, p=0.039) as compared with CEPI-CT>190 s (4.6% vs. 0.7%). Multivariable analysis after adjustment for other risk factors confirmed that baseline CEPI-CT<190 s was an independent correlate for death or MI (Hazard ratio 6.981, p=0.008). At T1 there was a significant prolongation of CEPI-CT (p=0.03) from 208+/-64 s to 240+/-59 s but T1 did not predict any event. CONCLUSIONS A CEPI-CT<190 s measured within the first 24 h following PCI predicts IST defined as the occurrence of death or MI. |
| Starting Page | 2396 |
| Ending Page | 2396 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://puma.isti.cnr.it/rmydownload.php?filename=cnr.ifc/cnr.ifc/2007-A0-141/2007-A0-141.pdf |
| PubMed reference number | 17555804v1 |
| Volume Number | 121 |
| Issue Number | 3 |
| Journal | Thrombosis research |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angina Pectoris Blood Platelet Disorders Blood Platelets Cardiovascular Diseases CepI protein, Burkholderia Cessation of life Dual Epinephrine Greater Hyperactive behavior Myocardial Infarction Myocardial Ischemia Patients Percutaneous Coronary Intervention Platelet Count measurement Stent Device Component Stent, device Thrombosis clopidogrel confirmation - ResponseLevel |
| Content Type | Text |
| Resource Type | Article |
