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Inhaled magnesium fluoride reverse bronchospasma.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gandia, Fedoua Rouatbi, Sonia Latiri, Imed Guénard, Hervé Jean-Pierre Tabka, Zouhair |
| Copyright Year | 2010 |
| Abstract | Asthma is a global health problem. Asthma attacks are becoming more severe and more resistant to usual treatment by beta(2) agonists nebulisation. The search for a new product that could reduce the morbidity of asthmatic disease seems necessary. The objective of this study was to compare the effectiveness of inhaled magnesium fluoride (MgF(2)) with that of magnesium sulphate (MgSO(4)) 15% alone and sodium fluoride (NaF) 0.5 M alone in rats pre-contracted by methacholine (MeCh). Fifty six adult male Wistar rats of medium weight 259 +/- 15 g were divided randomly into five groups. They inhaled respectively: MeCh, MgF(2) + NaCl 0.9%, MgF(2) + acetic acid, MgSO(4) 15% single and NaF (0.5 M) single. Airway resistances were measured after each dose of MeCh by pneumomultitest equipment. Results indicated that (1) MgF(2) + NaCl 0.9%, MgF(2) + acetic acid and MgSO(4) reversed significantly the methacholine-induced bronchial constriction in rats and had a bronchodilating effect at the moment of its administration (2) MgF(2) + acetic acid led to a greater decrease (P<0.05) of bronchial resistances when compared to that obtained from MgF(2) + NaCl 0.9%, NaF exclusively and MgSO(4) alone (3) inhaled NaF alone led to a significant bronchorelaxing effect (P<0.05) that starts at the sixth dose of MeCh (17 mg/L). As a matter of fact, MgF(2) dissolved in acetic acid and delivered in aerosol form reduces significantly bronchial spasm. In conclusion, MgF(2) can be used as a bronchodilator for diseases with bronchospasma such as asthma and chronic obstructive pulmonary disease (COPD). |
| Starting Page | 1280 |
| Ending Page | 1283 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/jsmr/46/3/46_3_157/_pdf/-char/en |
| PubMed reference number | 20647692v1 |
| Volume Number | 46 |
| Issue Number | 3 |
| Journal | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetic Acid Aerosol Dose Form Airway Obstruction Asthma Bronchial Spasm Bronchoconstriction Bronchodilator Agents Chronic Obstructive Airway Disease Inspiration function Lung Diseases, Obstructive Lung diseases Magnesium Sulfate Methacholine Morbidity - disease rate Paget's Disease, Mammary Sodium Chloride Sodium Fluoride Sulfate measurement Thioctic Acid magnesium fluoride |
| Content Type | Text |
| Resource Type | Article |
