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Miniaturized Lab-ona-Disc ( miniLOAD )
| Content Provider | Semantic Scholar |
|---|---|
| Author | Glass, Nick R. Shilton, Richie Chan, Peggy Pui Yik Yeo, Leslie Y. |
| Copyright Year | 2012 |
| Abstract | A miniaturized centrifugal microfl uidic platform for lab-on-a-chip applications is presented. Unlike its macroscopic Lab-on-a-CD counterpart, the miniature Lab-on-aDisc (miniLOAD) device does not require moving parts to drive rotation of the disc, is inexpensive, disposable, and signifi cantly smaller, comprising a 10-mm-diameter SU-8 disc fabricated through two-step photolithography. The disc is driven to rotate using surface acoustic wave irradiation incident upon a fl uid coupling layer from a pair of offset, opposing single-phase unidirectional transducers patterned on a lithium niobate substrate. The irradiation causes azimuthally oriented acoustic streaming with suffi cient intensity to rotate the disc at several thousand revolutions per minute. In this fi rst proof-of-concept, the capability of the miniLOAD platform to drive capillary-based valving and mixing in microfl uidic structures on a disc similar to much larger Lab-on-a-CD devices is shown. In addition, the ability to concentrate aqueous particle suspensions at radial positions in a channel in the disc dependent on the particles’ size is demonstrated. To the best of our knowledge, the miniLOAD concept is the fi rst centrifugal microfl uidic platform small enough to be self-contained in a handheld device. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://users.monash.edu/~lyeo/Dr_Leslie_Yeo/Publications_files/1881_ftp.pdf |
| Alternate Webpage(s) | http://users.monash.edu/~lyeo/Dr_Leslie_Yeo/CV_files/1881_ftp.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
