Loading...
Please wait, while we are loading the content...
Similar Documents
Cardioversion and digitalis. IV. Effect of beta adrenergic blockade.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wittenberg, S. M. Lown, Bernard |
| Copyright Year | 1969 |
| Abstract | Experiments were performed in anesthetized dogs to study some effects of propranolol, dextro-propranolol and ICI50,172 on digitalis-induced arrhythmias and digitalis-induced sensitization to electrical shock. When given in beta-blocking doses, propranolol did not abbreviate ouabain-induced ventricular tachycardia (VT) or decrease ouabain-induced sensitization to electrical shock. In larger doses, propranolol first controlled the arrhythmia without affecting shock sensitivity and then abolished both arrhythmia and shock sensitivity. Dextro-propranolol, a compound with nonspecific antiarrhythmic action equal to that of propranolol but with virtually no beta-blocking effect, abolished shock sensitivity, whereas IC150,172, a pure beta-blocking agent, did not. Beta-blocking doses of propranolol given to dogs bordering on digitalis toxicity but in normal sinus rhythm caused recurrence of sustained ventricular tachycardia. Reappearance of toxicity appeared to be related to a propranolol-induced decrease in heart rate, since it was averted during continuous electrical pacing of the atrium and reversed by isoproterenol administration. |
| Starting Page | 29 |
| Ending Page | 37 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/39/1/29.full.pdf?download=true |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/39/1/29.full.pdf |
| PubMed reference number | 5782806v1 |
| Volume Number | 39 |
| Issue Number | 1 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenergic beta-Antagonists Adverse reaction to drug Anti-Arrhythmia Agents Canis familiaris Digitalis preparation Isoproterenol Large Nasal sinus Ouabain Propranolol Sensitization (observable entity) Shock from electric current Tachycardia, Ventricular digitalis toxicity sustained ventricular tachycardia |
| Content Type | Text |
| Resource Type | Article |
