NDLI: Low-dose cortisol for symptoms of posttraumatic stress disorder.

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Low-dose cortisol for symptoms of posttraumatic stress disorder.

Content Provider	Semantic Scholar
Author	Aerni, Amanda Traber, Rafael Hock, C. Roozendaal, Benno Schelling, Gustav Papassotiropoulos, Andreas Nitsch, Roger M. Schnyder, Ulrich Quervain, Dominique J-F De
Copyright Year	2004
Abstract	OBJECTIVE Because elevated cortisol levels inhibit memory retrieval in healthy human subjects, the present study investigated whether cortisol administration might also reduce excessive retrieval of traumatic memories and related symptoms in patients with chronic posttraumatic stress disorder (PTSD). METHOD During a 3-month observation period, low-dose cortisol (10 mg/day) was administered orally for 1 month to three patients with chronic PTSD in a double-blind, placebo-controlled, crossover design. RESULTS In each patient investigated, there was a significant treatment effect, with cortisol-related reductions of at least 38% in one of the daily rated symptoms of traumatic memories, as assessed by self-administered rating scales. In accordance, Clinician-Administered PTSD Scale ratings assessed after each month showed cortisol-related improvements for reexperiencing symptoms and, additionally, in one patient for avoidance symptoms. CONCLUSIONS The results of this pilot study indicate that low-dose cortisol treatment reduces the cardinal symptoms of PTSD.
File Format	PDF HTM / HTML
DOI	10.1176/appi.ajp.161.8.1488
Alternate Webpage(s)	https://ils.unc.edu/bmh/neoref/nrschizophrenia/jsp/review/tmp/177.pdf
PubMed reference number	15285979
Alternate Webpage(s)	https://doi.org/10.1176/appi.ajp.161.8.1488
Journal	Medline
Volume Number	161
Issue Number	8
Journal	The American journal of psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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