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Age, body mass index, race and other determinants of steroid hormone variability: the HERITAGE Family Study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ukkola, Olavi H. Gagnon, Jacques Rankinen, Tuomo Thompson, Patricia A. Yuling Leon, Arthur S. Rao, D. Chandrasekhra Skinner, James S. Wilmore, Jack H. Bouchard, Claude |
| Copyright Year | 2001 |
| Abstract | OBJECTIVE AND METHODS To investigate from the HERITAGE Family Study database, 13 steroid hormones (androstane-3alpha, 17beta-diol glucuronide, androsterone glucuronide, cortisol, dehydroepiandrosterone (DHEA), DHEA ester (DHEAE), DHEA sulfate (DHEAS), dihydrotestosterone (DHT), estradiol, 17-hydroxyprogesterone, progesterone, pregnenolone ester, sex hormone binding globulin (SHBG) and testosterone in each sex for their relationships with age, body mass index (BMI), race and key lifestyle variables. Sample sizes varied from 676 to 750 per hormone. Incremental regression methods were used to examine the contributions of the variables to steroid hormone variability. RESULTS Age was a major predictor for most steroid hormones. The greatest contribution of age was a negative relationship with DHEAS (R(2)=0.39). BMI was also associated with the variability of several steroid hormones, being the most important predictor of SHBG (R(2)=0.20) and of testosterone (R(2)=0.12) concentrations. When age and BMI were included, race still contributed significantly to the variations in cortisol (R(2)=0.02 for men and 0.04 for women), DHT (R(2)=0.02 for men and 0.03 for women), and progesterone (R(2)=0.03 for women). Nevertheless, race appeared to be less important than age and BMI. In addition, lifestyle indicators (food and nutrient intakes, smoking and physical activity) influenced steroid hormone variability. Their contributions, however, were minor in most cases once age, BMI and race had been taken into account. CONCLUSIONS We conclude that age was the most important factor, followed by BMI, race and lifestyle factors in explaining steroid hormone variability. |
| Starting Page | 1 |
| Ending Page | 9 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://eje.bioscientifica.com/downloadpdf/journals/eje/145/1/1.pdf |
| PubMed reference number | 11415846v1 |
| Volume Number | 145 |
| Issue Number | 1 |
| Journal | European journal of endocrinology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 17-alpha-Hydroxyprogesterone Androstenediol Body Dysmorphic Disorders Body mass index Dehydroepiandrosterone Sulfate Dihydrotestosterone Esters Estradiol Exercise Globulins Glycol Gonadal Steroid Hormones Hydrocortisone Increment NG-Nitroarginine Methyl Ester Progesterone SHBG gene Sex Factors Sex Hormone-Binding Globulin Smoke Steroid hormone Steroids Testosterone androsterone glucuronide |
| Content Type | Text |
| Resource Type | Article |
