Interferon-β increases the stimulatory capacity of monocyte-derived dendritic cells to induce IL-13, IL-5 and IL-10 in autologous T-cells

Content Provider	Semantic Scholar
Author	Wiesemann, Elke Sönmez, Daniela Heidenreich, Fedor Windhagen, Anja
Copyright Year	2002
Abstract	Dendritic cells (DCs) are key regulators of immune responses and have been associated with autoimmunity in animal models and human disease. The effects of interferon beta (IFN-beta), an immunomodulatory cytokine used in multiple sclerosis (MS) therapy, on DCs are not well understood. Monocyte-derived DCs at different stages of maturation were stimulated with IFN-beta and DC-phenotype and stimulatory function were measured. IFN-beta inhibited the development of DCs at early stages but enhanced DC maturation. Moreover, IFN-beta enhanced the capacity of DCs to stimulate autologous T-cells to secrete IL-13, IL-10 and IL-5. Thus, IFN-beta has both immunostimulatory and immunosuppressive effects on DCs depending on the stage of maturation.
Starting Page	160
Ending Page	169
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1016/S0165-5728(01)00482-9
PubMed reference number	11880160
Journal	Medline
Volume Number	123
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0165572801004829
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0165572801004829?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0165-5728%2801%2900482-9
Journal	Journal of Neuroimmunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article