Loading...
Please wait, while we are loading the content...
Similar Documents
Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain
| Content Provider | Semantic Scholar |
|---|---|
| Author | Reynolds, Lindsay M. Cochran, Susan M. Morris, Brian J. Pratt, Judith A. Reynolds, Gavin P. |
| Copyright Year | 2005 |
| Abstract | Administration of phencyclidine (PCP) to both humans and animals models the symptoms of schizophrenia. Brain concentrations of N-acetylaspartate (NAA) are reduced in this disease, reflecting neuronal dysfunction. This study investigates the effects in rats of a chronic intermittent regime of PCP on NAA and its precursor N-acetylaspartylglutamate (NAAG) in rat frontal and temporal cortex, hippocampus and striatum, determined by HPLC. We found significant PCP-induced deficits of NAA and NAAG only in the temporal cortex; NAAG was significantly elevated in the hippocampus. These changes closely reflect postmortem findings reported in schizophrenia. |
| Starting Page | 147 |
| Ending Page | 152 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.schres.2004.02.003 |
| PubMed reference number | 15653257 |
| Journal | Medline |
| Volume Number | 73 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0920996404000519 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0920996404000519?dgcid=api_sd_search-api-endpoint |
| Journal | Schizophrenia Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
