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CYP2B6 983T>C polymorphism is prevalent in West Africa but absent in Papua New Guinea: implications for HIV/AIDS treatment.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mehlotra, Rajeev K. Bockarie, Moses Zimmerman, Peter A. |
| Copyright Year | 2007 |
| Abstract | AIMS To determine the prevalence of the novel CYP2B6 functional polymorphism 983T>C in Papua New Guinea where HIV/AIDS poses a significant health problem. METHOD We genotyped Papua New Guineans (PNG, n = 174), West Africans (WA, n = 170), and North Americans (NA, n = 361). RESULTS The polymorphism was absent in PNG, while its overall frequency was 4.7% in WA. Among NA, the polymorphism was present in African-Americans (7.5%) and Hispanic-Americans (1.1%) but not in Caucasian-Americans and Asian-Americans. Haplotype analysis indicated that 983T>C was present alone as the CYP2B6*18 allele in WA and African-Americans. CONCLUSIONS Significant interethnic differences occur at the CYP2B6 locus, which may influence treatment outcomes with efavirenz. |
| File Format | PDF HTM / HTML |
| DOI | 10.1111/j.1365-2125.2007.02884.x |
| PubMed reference number | 17391322 |
| Journal | Medline |
| Volume Number | 64 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://www.krepublishers.com/02-Journals/T-Anth/Anth-09-0-000-000-2007-Web/Anth-09-1-000-000-2007-Abst-PDF/Anth-09-1-001-037-2007-464-Bhasin-M-K/Anth-09-1-001-037-2007-464-Bhasin-M-K-Tt.pdf |
| Journal | British journal of clinical pharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
