Dietary supplementation with trans-11- and trans-12-18 : 1 increases cis-9, trans-11-conjugated linoleic acid in human immune cells, but without effects on biomarkers of immune function and inflammation.

Content Provider	Semantic Scholar
Author	Kuhnt, Katrin Kraft, Jana Vogelsang, Heinz Eder, Klaus Kratzsch, Jürgen Jahreis, Gerhard
Copyright Year	2007
Abstract	Trans-fatty acid intake is associated with an increased risk of CHD and diabetes. The effects of single trans-fatty acid isomers are largely unexplored. The present study examined the effects of a 6-week supplementation with two trans-18 : 1 isomers (trans-11 and trans-12) in human subjects on immune cells, several inflammatory and immunological biomarkers (for example, IL, TNFalpha, C-reactive protein, adiponectin, intercellular adhesion molecule-1, prostacyclin, phagocytic process). Following a 2-week adaptation period without supplements, the test group (n 12) received vaccenic acid (trans-11-18:1) and trans-12-18 : 1 in equal amounts (6.0 g/d) for 6 weeks. The control group (n 12) consumed an oil without trans-fatty acids and conjugated linoleic acids (CLA). Samples were collected at the end of both periods. Trans-11- and trans-12-18 : 1 were significantly increased in cellular lipids. The endogenous synthesis of cis-9, trans-11-CLA from trans-11-18 : 1 was demonstrated via increased CLA in cellular lipids of the test group. Generally, trans-isomer supplementation did not affect either inflammatory biomarkers (for example, IL-6, IL-8, TNFalpha) or immune function (for example, phagocytosis) during the present study. The dietary supplementation of trans-11- and trans-12-18 : 1 (6 g/d) and their accumulation in leucocytes had no effects on biomarkers of inflammation and immune function. However, because of the limited data on the safety of trans-fatty acid intake and effects of individual trans isomers on human health (for example, trans-9-18 : 1, trans-10-18 : 1) at present, it is prudent to reduce trans-fat intake in general.
File Format	PDF HTM / HTML
DOI	10.1017/S0007114507685183
PubMed reference number	17367566
Journal	Medline
Volume Number	97
Issue Number	6
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/ED30F29B16B394CEBF30909779667BAE/S0007114507685183a.pdf/dietary_supplementation_with_trans11_and_trans1218_1_increases_cis9_trans11conjugated_linoleic_acid_in_human_immune_cells_but_without_effects_on_biomarkers_of_immune_function_and_inflammation.pdf
Alternate Webpage(s)	https://doi.org/10.1017/S0007114507685183
Journal	The British journal of nutrition
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article