NDLI: Silk matrix for tissue engineered anterior cruciate ligaments.

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Silk matrix for tissue engineered anterior cruciate ligaments.

Content Provider	Semantic Scholar
Author	Altman, Gregory H. Horan, Rebecca L. Moreau, Jodie E. Martin, Ivan Richmond, John C. W. Kaplan, David L.
Copyright Year	2002
Abstract	A silk-fiber matrix was studied as a suitable material for tissue engineering anterior cruciate ligaments (ACL). The matrix was successfully designed to match the complex and demanding mechanical requirements of a native human ACL, including adequate fatigue performance. This protein matrix supported the attachment, expansion and differentiation of adult human progenitor bone marrow stromal cells based on scanning electron microscopy, DNA quantitation and the expression of collagen types I and III and tenascin-C markers. The results support the conclusion that properly prepared silkworm fiber matrices, aside from providing unique benefits in terms of mechanical properties as well as biocompatibility and slow degradability, can provide suitable biomaterial matrices for the support of adult stem cell differentiation toward ligament lineages. These results point toward this matrix as a new option for ACL repair to overcome current limitations with synthetic and other degradable materials.
Starting Page	89
Ending Page	100
Page Count	12
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://orion.bme.columbia.edu/lulab/pdf/Altman-silk-ACL-MSC-2002.pdf
PubMed reference number	12182315v1
Volume Number	23
Issue Number	20
Journal	Biomaterials
Language	English
Access Restriction	Open
Subject Keyword	Adult Stem Cells Anterior Cruciate Ligament Bone Marrow Cell Differentiation process Fatigue Ligaments Quantitation Stem Cell Differentiation Tissue Engineering Tissue fiber benefit biocompatibility
Content Type	Text
Resource Type	Article

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