The Influence of Propolis Ingestion on Redox State of Human Serum Albumin : a Study of Patients under Severe Oxidative Stress

Content Provider	Semantic Scholar
Author	Era, Seiichi Imai, Hajime Hayashi, Takashi Okihara, Koji Nakatsuma, Akira Yamada, Hidekazu
Copyright Year	2004
Abstract	Human serum albumin (HSA) is a mixture of mercaptalbumin (HMA, reduced form) and nonmercaptalbumin (HNA, oxidized form). HMA, possessing a single sulfhydryl residue, is responsible for the largest fraction of reactive sulfhydryl in extracellular fluids and therefore it seems to participate largely in the extracellular antioxidant system. We have developed a convenient high-performance liquid chromatographic (HPLC) system for the clear separation from HSA to HMA and HNA. By this method, a mean value of [HMA/(HMA+HNA)], i.e. f(HMA) for healthy young male subjects was 73.2% (n = 20). In the present study, we examined the influence of propolis ingestion on the redox state of HSA from patients under severe oxidative stress such as a cancer therapy. In the case of a patient with liver cirrhosis and esophageal cancer (male, 68 yr), f(HMA) value before the radiation therapy without propolis ingestion was 66.6%. However, during the radiation therapy for 2 weeks, he took ten propolis tablets/day (525 mg of Brazilian propolis extract/day) every day and continued to take them for more 4 weeks. Values for f(HMA) just before, immediately after, and 4 weeks after radiation therapy, were 63.5, 67.7 and 74.1%, respectively. These evidences suggest that oxidative status due to the radiation therapy might be attenuated by propolis supplementation. Furthermore, a gradual increase in f(HMA) value indicates that the antioxidant properties of propolis might augment the total antioxidant capacity of the patient with cancer.
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