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A new facile synthesis of dimethyl 4-(2-(2,6-bis(methoxycarbonyl)pyridin-4-yl)vinyl) pyridine-2,6-dicarboxylate
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gu, Guoliang Lu, Ming |
| Copyright Year | 2010 |
| Abstract | A new facile synthesis of pyridine dicarboxylic acid derivative, dimethyl 4-(2-(2,6-bis(methoxycarbonyl)pyridin-4-yl)vinyl)pyridine-2,6-dicarboxylate (DVDPA), from dimethyl 4-(chloromethyl)pyridine-2,6-dicarboxylate (CMDPA) in presence of nitrogen bases has been described. The influences of different base/CMDPA molar ratio and different nitrogen bases were also investigated. The result has shown that the yield could reach 81 % when triethylamine was used and the molar ratio of base/CMDPA was 2.4. The overall yield of title compound via the three-step synthesis starting from dimethyl 4-(hydroxylmethyl)pyridine-2,6-dicarboxylate (HMDPA) was improved to 69 %. |
| Starting Page | 165 |
| Ending Page | 168 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.20450/mjcce.2010.163 |
| Alternate Webpage(s) | http://www.mjcce.org.mk/index.php/MJCCE/article/download/163/62 |
| Alternate Webpage(s) | https://doi.org/10.20450/mjcce.2010.163 |
| Volume Number | 29 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |