Phosphorylation of disaccharides with inorganic cyclo-triphosphate in aqueous solution.

Content Provider	Semantic Scholar
Author	Inoue, Hideko Tone, Naoto Nakayama, Hirokazu Tsuhako, Mitsutomo
Copyright Year	2002
Abstract	The phosphorylation of disaccharides by inorganic cyclo-triphosphate (P(3m)) with a six-membered ring was examined in aqueous solution. In the phosphorylation of cellobiose, lactose, and alpha,alpha-trehalose with P(3m), beta-D-glucopyranosyl-(1-->4)-beta-D-glucopyranosyl 1-triphosphate, beta-D-galactopyranosyl-(1-->4)-beta-D-glucopyranosyl 1-triphosphate, and 3-O-triphospho-alpha-D-glucopyranosyl-(1-->1)-alpha-D-glucopyranoside were synthesized with maximum yields of 28%, 35%, and 20%, respectively. In the reactions of maltose and sucrose with P(3m), two phosphorylated products were obtained in yields of 42% and 58%, respectively. The main phosphorylated products were assigned to alpha-D-glucopyranosyl-(1-->4)-beta-D-glucopyranosyl 1-triphosphate and beta-D-fructofuranosyl-(2-->1)-2-O-triphospho-alpha-D-glucopyranoside by heteronuclear multiple bond correlation (HMBC) NMR. The phosphorylation mechanism of disaccharides with P(3m) is discussed.
Starting Page	868
Ending Page	868
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/cpb/50/11/50_11_1453/_pdf
PubMed reference number	12419909v1
Volume Number	50
Issue Number	11
Journal	Chemical & pharmaceutical bulletin
Language	English
Access Restriction	Open
Subject Keyword	Cellobiose Disaccharides Lactose Maltose Multiple Myeloma PersonNameUse - assigned Sucrose Trehalose beta Thalassemia triphosphate
Content Type	Text
Resource Type	Article