Carotid Intima-Media Thickness Progression and Risk of Vascular Events in People With Diabetes: Results From the PROG-IMT Collaboration

Content Provider	Semantic Scholar
Author	Lorenz, Matthias W. Price, Jackie F. Robertson, Christine Bots, Michiel L. Polak, Joseph F. Poppert, Holger Kavousi, Maryam Dörr, Marcus Stensland, Eva Ducimetiere, Pierre Ronkainen, Kimmo Kiechl, Stefan Sitzer, Matthias Rundek, Tatjana Lind, Lars Liu, Jing Bergström, Göran M. L. Grigore, Liliana Bokemark, Lena Friera, Alfonsa Yanez, David N. Bickel, Horst Ikram, Mohammad A. Völzke, Henry Johnsen, Stein Harald Empana, Jean Philippe Tuomainen, Tomi-Pekka Willeit, Peter Steinmetz, Helmuth Desvarieux, Moise Xie, Wuxiang Schmidt, Caroline Norata, Giuseppe Danilo Suárez, Carmen Sander, Dirk Hofman, Albert Schminke, Ulf Mathiesen, Ellisiv Plichart, Matthieu Kauhanen, Jussi Willeit, Johann Sacco, Ralph L. McLachlan, Stela Zhao, Dong Fagerberg, Björn Catapano, Alberico L. Gabriel, Rafael Franco, Òscar Bülbül, Alpaslan Scheckenbach, Frank Pflug, Anja Thompson, Simon Giles
Copyright Year	2015
Abstract	OBJECTIVE Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with diabetes. However, the association of CIMT change in repeated examinations with subsequent CVD events is uncertain, and its use as a surrogate end point in clinical trials is controversial. We aimed at determining the relation of CIMT change to CVD events in people with diabetes. RESEARCH DESIGN AND METHODS In a comprehensive meta-analysis of individual participant data, we collated data from 3,902 adults (age 33-92 years) with type 2 diabetes from 21 population-based cohorts. We calculated the hazard ratio (HR) per standard deviation (SD) difference in mean common carotid artery intima-media thickness (CCA-IMT) or in CCA-IMT progression, both calculated from two examinations on average 3.6 years apart, for each cohort, and combined the estimates with random-effects meta-analysis. RESULTS Average mean CCA-IMT ranged from 0.72 to 0.97 mm across cohorts in people with diabetes. The HR of CVD events was 1.22 (95% CI 1.12-1.33) per SD difference in mean CCA-IMT, after adjustment for age, sex, and cardiometabolic risk factors. Average mean CCA-IMT progression in people with diabetes ranged between -0.09 and 0.04 mm/year. The HR per SD difference in mean CCA-IMT progression was 0.99 (0.91-1.08). CONCLUSIONS Despite reproducing the association between CIMT level and vascular risk in subjects with diabetes, we did not find an association between CIMT change and vascular risk. These results do not support the use of CIMT progression as a surrogate end point in clinical trials in people with diabetes.
Starting Page	1921
Ending Page	1929
Page Count	9
File Format	PDF HTM / HTML
DOI	10.2337/dc14-2732
PubMed reference number	26180107
Journal	Medline
Volume Number	38
Journal	Diabetes care
Alternate Webpage(s)	http://care.diabetesjournals.org/content/diacare/early/2015/07/08/dc14-2732.full.pdf
Alternate Webpage(s)	https://doi.org/10.2337/dc14-2732
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article