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Inotropic Effects of Prostacyclins on the Right Ventricle Are Abolished in Isolated Rat Hearts With Right-Ventricular Hypertrophy and Failure.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Holmboe, Sarah Andersen, Asger Johnsen, Jacob Nielsen, Jan Møller Nørregaard, Rikke Bøtker, Hans Erik Clapp, Lh. Nielsen-Kudsk, Jens Erik |
| Copyright Year | 2017 |
| Abstract | BACKGROUND Prostacyclin mimetics are vasodilatory agents used in the treatment of pulmonary arterial hypertension. The direct effects of prostanoids on right-ventricular (RV) function are unknown. We aimed to investigate the direct effects of prostacyclin mimetics on RV function in hearts with and without RV hypertrophy and failure. METHODS Wistar rats were subjected to pulmonary trunk banding to induce compensated RV hypertrophy (n = 32) or manifest RV failure (n = 32). Rats without banding served as healthy controls (n = 30). The hearts were excised and perfused in a Langendorff system and subjected to iloprost, treprostinil, epoprostenol, or MRE-269 in increasing concentrations. The effect on RV function was evaluated using a balloon-tipped catheter inserted into the right ventricle. RESULTS In control hearts, iloprost, treprostinil, and MRE-269 improved RV function. The effect was, however, absent in hearts with RV hypertrophy and failure. Treprostinil and MRE-269 even impaired RV function in hearts with manifest RV failure. CONCLUSIONS Iloprost, treprostinil, and MRE-269 improved RV function in the healthy rat heart. RV hypertrophy abolished the positive inotropic effect, and in the failing right ventricle, MRE-269 and treprostinil impaired RV function. This may be related to changes in prostanoid receptor expression and reduced coronary flow reserve in the hypertrophic and failing right ventricle. |
| Starting Page | 1 |
| Ending Page | 12 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://discovery.ucl.ac.uk/1517858/1/00005344-900000000-98762.pdf |
| PubMed reference number | 27652910v1 |
| Alternate Webpage(s) | https://doi.org/10.1097/FJC.0000000000000435 |
| DOI | 10.1097/FJC.0000000000000435 |
| Journal | Journal of cardiovascular pharmacology |
| Volume Number | 69 |
| Issue Number | 1 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Epoprostenol Heart Ventricle Heart failure Hypertensive disease Iloprost Liver Failure, Acute MRE 269 Prostaglandin Receptor Prostaglandins I Pulmonary Hypertension Pulmonary artery structure Right Ventricular Hypertrophy Right ventricular structure Treprostinil Ventricular Fibrillation |
| Content Type | Text |
| Resource Type | Article |
