NDLI: Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions.

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Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions.

Content Provider	Semantic Scholar
Author	Novák, Béla Csikász-Nagy, Attila Győrffy, Béla Chen, Katherine C. Tyson, John J.
Copyright Year	1998
Abstract	All events of the fission yeast cell cycle can be orchestrated by fluctuations of a single cyclin-dependent protein kinase, the Cdc13/Cdc2 heterodimer. The G1/S transition is controlled by interactions of Cdc13/Cdc2 and its stoichiometric inhibitor, Rum1. The G2/M transition is regulated by a kinase-phosphatase pair, Wee1 and Cdc25, which determine the phosphorylation state of the Tyr-15 residue of Cdc2. The meta/anaphase transition is controlled by interactions between Cdc13/Cdc2 and the anaphase promoting complex, which labels Cdc13 subunits for proteolysis. We construct a mathematical model of fission yeast growth and division that encompasses all three crucial checkpoint controls. By numerical simulations we show that the model is consistent with a broad selection of cell cycle mutants, and we predict the phenotypes of several multiple-mutant strains that have not yet been constructed.
Starting Page	185
Ending Page	200
Page Count	16
File Format	PDF HTM / HTML
DOI	10.1016/S0301-4622(98)00133-1
Alternate Webpage(s)	https://www.researchgate.net/profile/Bela_Novak/publication/13632875_Mathematical_model_of_the_fission_yeast_cell_cycle_with_checkpoint_controls_at_the_G1S_G2M_and_metaphaseanaphase_transitions/links/0912f50be2b7294f40000000.pdf
Alternate Webpage(s)	http://www.cellcycle.bme.hu/articles/pombe/biophys/novak.pdf
PubMed reference number	9652094
Alternate Webpage(s)	https://doi.org/10.1016/S0301-4622%2898%2900133-1
Journal	Medline
Volume Number	72
Issue Number	1-2
Journal	Biophysical chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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