Influence of the Insertion Method of Aryl‐Extended Calix[4]pyrroles into Liposomal Membranes on Their Properties as Anion Carriers

Content Provider	Semantic Scholar
Author	Martínez-Crespo, Luis Sun-Wang, Jia Liang Ferreira, Pedro Mirabella, Chiara F. M. Aragay, Gemma Ballester, Pablo
Copyright Year	2019
Abstract	We disclose the results of our investigations on the influence that the insertion method of aryl-extended calix[4]pyrrole into liposomal membranes exerts on their properties as anion carriers. We use the standard HPTS assay to assess the transport properties of the carriers. We show that the post-insertion of the carrier, as DMSO solution, assigns better transport activities to the "two-wall" α,α-aryl-extended calix[4]pyrrole 1 compared to the "four-wall" α,α,α,α-counterpart 2. Notably, opposite results were obtained when the carriers were pre-inserted into the liposomal membranes. We assign this difference to an improved incorporation of carrier 2 into the membrane when delivered by the pre-insertion method. On the other hand, carrier 1 shows comparable levels of transport independently of the method used for its incorporation. Thus, an accurate comparison of the chloride transport activities featured by these two carriers demands their pre-incorporation in the liposomal membranes. In contrast, using the lucigenin assay with the pre-insertion method both carriers displayed similar transport efficiencies.
Starting Page	4775
Ending Page	4781
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1002/chem.201806169
PubMed reference number	30830693
Journal	Medline
Volume Number	25
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/05/CHEM-25-4775.PMC6593748.pdf
Alternate Webpage(s)	https://doi.org/10.1002/chem.201806169
Journal	Chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article