Findings from two large randomized controlled trials on renal replacement therapy in acute kidney injury

Content Provider	Semantic Scholar
Author	Yoshida, Teruhiko Komaru, Yohei Matsuura, Ryo Miyamoto, Yoshihisa Yoshimoto, Kohei Noiri, Eisei Nangaku, Masaomi Yahagi, Naoki Doi, Kent
Copyright Year	2016
Abstract	Many issues regarding the management of renal replacement therapy (RRT) in acute kidney injury (AKI) including timing of initiation, selection of RRT modality, and optimal dosing remain to be resolved. Two major randomized controlled trials, the Veterans Affairs/National Institutes of Health (VA/NIH) Acute Renal Failure Trial Network (ATN) and the Randomized Evaluation of Normal versus Augmented Level (RENAL) studies, which were elaborately designed to evaluate the benefit for delivering RRT of higher intensity in critically ill patients, were characterized by their sophisticated design, large sample sizes, and comprehensive data collection. Although no beneficial effect of higher intensity RRT was demonstrated by these studies, many ancillary studies conducted subanalyses which provided additional findings on other important clinical questions that remained unsolved. This review aims to overview the useful information obtained by the VA/NIH ATN and the RENAL studies to gain useful insights for optimal RRT in AKI.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://rrtjournal.biomedcentral.com/track/pdf/10.1186/s41100-016-0027-1
Language	English
Access Restriction	Open
Subject Keyword	Critical Illness Data Collection Kidney Diseases Kidney Failure, Acute Modality (human–computer interaction) Patients Randomized algorithm Renal Replacement Therapy Sample Size Transcription Initiation kidney injury
Content Type	Text
Resource Type	Article