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Effects of subthalamic nucleus deep brain stimulation and l-dopa on blinking in Parkinson's disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bologna, Matteo Fasano, Alfonso Modugno, Nicola Fabbrini, Giovanni Berardelli, Alfredo |
| Copyright Year | 2012 |
| Abstract | In this study we asked whether subthalamic nucleus deep brain stimulation (STN-DBS) alone, or in combination with l-dopa, modifies voluntary, spontaneous and reflex blinking in patients with Parkinson's disease (PD). Sixteen PD patients who underwent STN-DBS were studied in four experimental conditions: without STN-DBS and without l-dopa, STN-DBS alone, l-dopa alone and STN-DBS plus l-dopa. The results were compared with those obtained in 15 healthy controls. Voluntary blinking was assessed by asking participants to blink as fast as possible; spontaneous blinking was recorded during two 60s rest periods; reflex blinking was evoked by electrical stimulation of the supraorbital nerve. Blinking were recorded and analysed with the SMART motion system. STN-DBS increased the peak velocity and amplitude for both the closing and opening voluntary blink phases, but prolonged the inter-phase pause duration. l-dopa had no effects on voluntary blinking but reversed the increased inter-phase pause duration seen during STN-DBS. Spontaneous blink rate increased after either STN-DBS or l-dopa. Reflex blinking kinematics were not modified by STN-DBS or l-dopa. The STN-DBS effects on voluntary blinking kinematics and spontaneous blinking rate may occur as results of changes of cortico-basal ganglia activity. The prolonged pause duration of voluntary blinking indicates that STN-DBS has detrimental effects on the cranial region. These results also shed light on the pathophysiology of eyelids opening apraxia following STN-DBS. |
| Starting Page | 265 |
| Ending Page | 272 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.expneurol.2012.02.004 |
| PubMed reference number | 22366535 |
| Journal | Medline |
| Volume Number | 235 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0014488612000635 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0014488612000635?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.expneurol.2012.02.004 |
| Journal | Experimental Neurology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
