Effects of Purified and Unpurified Multi-walled Carbon Nanotubes in Mammalian Cell Lines

Content Provider	Semantic Scholar
Author	Young, Ryoo Zaw Kim, Young Hun Sung, Sijin Park, Hyeoung Woo Kim, Do-Hyhung Sanggyu
Copyright Year	2010
Abstract	Multi-walled carbon nanotubes are widely used nanomaterials. Toxic effects of MWCNTs were revealed by various studies, thus prompting concerns about the effects of MWCNTs on human health and the environment. MWCNTs can be aerosolized in ambient air, and absorbed into the body through the respiratory tract. Inhaled MWCNTs can induce harmful effects on the respiratory tract and on the circulatory system. Important factors related to the toxicity of MWCNTs, such as the surface area of the nanotubes and the amount of catalytic metal included, have been revealed by various studies. These factors have an interdependent effect on MWCNT toxicity, which may differ according to the type of MWCNT. In this study, we compared the effects of purified and unpurified MWCNTs on A549, Jurkat, and THP-1 cell lines, and found that the purified and unpurified MWCNTs have different effects according to cell type, concentration, and duration of exposure. In particular, MWCNT-induced cell-cycle variation differs according to concentration of MWCNTs and duration of treatment; In the case of 24 hr exposure, percentages of S-phase in the cell-cycle are increased, whereas in the cell lines exposed to MWCNTs for 72 hr, percentages of G0/G1-phase are increased.
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Alternate Webpage(s)	http://konsys-t.tanger.cz/files/proceedings/nanocon_10/lists/papers/451.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article