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Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lin, Yihuang Zhang, Huifang Chen, Yucai He, Yangyang Wang, Shoubao Fang, Lianhua Lv, Yang Du, Guan-Hua |
| Copyright Year | 2017 |
| Abstract | The purpose of this study was to investigate the effects of salvianolic acid A (SAA) in systemic lupus erythematosus (SLE) induced by pristane in BALB/c mice. Lupus mice were established by confirming elevated levels of autoantibodies and IL-6 after intraperitoneal injection of pristane. Mice were then treated with daily oral doses of SAA for 5 months in parallel with mice treated with prednisone and aspirin as positive controls. The levels of autoantibodies were monitored at monthly intervals and nephritic symptoms observed by hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS) staining. Western blot analysis of renal tissue was also employed. SAA treatment caused a significant reduction in the levels of anti-Sm autoantibodies and reduced renal histopathological changes and pathological effects. SAA treatment also significantly inhibited the phosphorylation of IKK, IκB and NFκB in renal tissues of lupus mice. In conclusion, the results suggest that SAA alleviates renal injury in pristane-induced SLE in BALB/c mice through inhibition of phosphorylation of IKK, IκB and NFκB. |
| Starting Page | 159 |
| Ending Page | 166 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.apsb.2016.07.001 |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/45/main.PMC5343112.pdf |
| PubMed reference number | 28303221 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.apsb.2016.07.001 |
| Journal | Medline |
| Volume Number | 7 |
| Journal | Acta pharmaceutica Sinica. B |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
