NDLI: Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile.

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Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile.

Content Provider	Semantic Scholar
Author	Neben, Kai Giesecke, Christian Schweizer, Silja Ho, Anthony D. Kraemer, Alwin
Copyright Year	2003
Abstract	Genetic instability is a common feature in acute myeloid leukemia (AML). Centrosome aberrations have been described as a possible cause of aneuploidy in many human tumors. To investigate whether centrosome aberrations correlate with cytogenetic findings in AML, we examined a set of 51 AML samples by using a centrosome-specific antibody to pericentrin. All 51 AML samples analyzed displayed numerical and structural centrosome aberrations (36.0% +/- 16.6%) as compared with peripheral blood mononuclear cells from 21 healthy volunteers (5.2% +/- 2.0%; P <.0001). In comparison to AML samples with normal chromosome count, the extent of numerical and structural centrosome aberrations was higher in samples with numerical chromosome changes (50.5% +/- 14.2% versus 34.3% +/- 12.2%; P <.0001). When the frequency of centrosome aberrations was analyzed within cytogenetically defined risk groups, we found a correlation of the extent of centrosome abnormalities to all 3 risk groups (P =.0015), defined as favorable (22.5% +/- 7.3%), intermediate (35.3% +/- 13.1%), and adverse (50.3% +/- 15.6%). These results indicate that centrosome defects may contribute to the acquisition of chromosome aberrations and thereby to the prognosis in AML.
Starting Page	406
Ending Page	415
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/early/2002/06/28/blood-2002-04-1188.full.pdf?sso-checked=true
PubMed reference number	12393441v1
Volume Number	101
Issue Number	1
Journal	Blood
Language	English
Access Restriction	Open
Subject Keyword	Aneuploidy Centrosome Congenital Abnormality Congenital chromosomal disease Leukemia, Myelocytic, Acute Myeloid Leukemia Neoplasms PCNT gene Tooth Abnormalities Ventricular Septal Defects peripheral blood
Content Type	Text
Resource Type	Article

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