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Synthesis of Oil-Laden Poly(ethylene glycol) Diacrylate Hydrogel Nanocapsules from Double Nanoemulsions.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Mengwen Nowak, Maksymilian Molina, Paula Malo De Abramovitch, Michael Santizo, Katherine Mitragotri, Samir Helgeson, Matthew E. |
| Copyright Year | 2017 |
| Abstract | Multiple emulsions have received great interest due to their ability to be used as templates for the production of multicompartment particles for a variety of applications. However, scaling these complex droplets to nanoscale dimensions has been a challenge due to limitations on their fabrication methods. Here, we report the development of oil-in-water-in-oil (O1/W/O2) double nanoemulsions via a two-step high-energy method and their use as templates for complex nanogels comprised of inner oil droplets encapsulated within a hydrogel matrix. Using a combination of characterization methods, we determine how the properties of the nanogels are controlled by the size, stability, internal morphology, and chemical composition of the nanoemulsion templates from which they are formed. This allows for identification of compositional and emulsification parameters that can be used to optimize the size and oil encapsulation efficiency of the nanogels. Our templating method produces oil-laden nanogels with high oil encapsulation efficiencies and average diameters of 200-300 nm. In addition, we demonstrate the versatility of the system by varying the types of inner oil, the hydrogel chemistry, the amount of inner oil, and the hydrogel network cross-link density. These nontoxic oil-laden nanogels have potential applications in food, pharmaceutical, and cosmetic formulations. |
| Starting Page | 6116 |
| Ending Page | 6126 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/acs.langmuir.7b01162 |
| PubMed reference number | 28605186 |
| Journal | Medline |
| Volume Number | 33 |
| Issue Number | 24 |
| Alternate Webpage(s) | https://cloudfront.escholarship.org/dist/prd/content/qt1ft7w355/qt1ft7w355.pdf?t=osxsat |
| Alternate Webpage(s) | https://doi.org/10.1021/acs.langmuir.7b01162 |
| Journal | Langmuir : the ACS journal of surfaces and colloids |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
