Absence or Reduction of Carbonic Anhydrase II in the Red Cells of the Beluga Whale and Llama: Implications for Adaptation to Hypoxia

Content Provider	Semantic Scholar
Author	Yang Hewett-Emmett, David Tashian, Richard E.
Copyright Year	2004
Abstract	Carbonic anhydrase (CA) expression was examined in the red cells of two mammals that have adapted to low oxygen stress: the llama, which has adapted to high altitudes, and the beluga (or white) whale, which routinely dives for extended periods. Immunodiffusion analyses of their Hb-free hemolysates and partial amino acid sequencing of their HPLC-separated nonheme proteins indicate that the low-activity CA I isozyme is the major nonheme protein in erythrocytes of both the beluga whale and the llama. The high-activity CA II isozyme was not detected in the whale red cells but was present at low levels in erythrocytes of the llama. These results suggest that the absence or decrease in the expression of the high-activity CA II isozyme may be advantageous under hypoxic conditions.
Starting Page	241
Ending Page	252
Page Count	12
File Format	PDF HTM / HTML
DOI	10.1023/A:1001939504944
PubMed reference number	11131338
Journal	Medline
Volume Number	38
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1023/A:1001939504944
Alternate Webpage(s)	https://deepblue.lib.umich.edu/bitstream/handle/2027.42/44163/10528_2004_Article_226852.pdf;sequence=1
Alternate Webpage(s)	https://doi.org/10.1023/A%3A1001939504944
Journal	Biochemical Genetics
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article