Enhancement of feeding suppression by PYY3-36 in rats with area postrema ablations

Content Provider	Semantic Scholar
Author	Cox, James E. Randich, Alan
Copyright Year	2004
Abstract	We investigated suppression of food intake by intraperitoneal (IP) injections of peptide YY(3-36) (PYY(3-36)) (24, 60, or 150 microg/kg) in rats with ablations of the area postrema (APX) and in controls with sham ablations. In controls, PYY(3-36)-induced suppression was modest and short-lived, averaging 20% at most and persisting less than 6h. The highest dose tested (150 microg/kg) was even less effective than were the two lesser doses after 3h. APX did not diminish the potency of these effects of PYY(3-36). In fact, the magnitude of suppression produced by the greatest dose of PYY(3-36) in APX rats was significantly greater than in controls and PYY(3-36)-induced suppression was still present at 24h.
Starting Page	985
Ending Page	989
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/j.peptides.2004.03.003
PubMed reference number	15203245
Journal	Medline
Volume Number	25
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0196978104001044
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0196978104001044?dgcid=api_sd_search-api-endpoint
Journal	Peptides
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article