NDLI: Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling.

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Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling.

Content Provider	Semantic Scholar
Author	Crane, Janet L.
Copyright Year	2014
Abstract	During bone resorption, abundant factors previously buried in the bone matrix are released into the bone marrow microenvironment, which results in recruitment and differentiation of bone marrow mesenchymal stem cells (MSCs) for subsequent bone formation, temporally and spatially coupling bone remodeling. Parathyroid hormone (PTH) orchestrates the signaling of many pathways that direct MSC fate. The spatiotemporal release and activation of matrix TGF-β during osteoclast bone resorption recruits MSCs to bone-resorptive sites. Dysregulation of TGF-β alters MSC fate, uncoupling bone remodeling and causing skeletal disorders. Modulation of TGF-β or PTH signaling may reestablish coupled bone remodeling and be a potential therapy.
File Format	PDF HTM / HTML
DOI	10.1172/JCI70050
PubMed reference number	24487640
Journal	Medline
Volume Number	124
Issue Number	2
Alternate Webpage(s)	https://www.jci.org/articles/view/70050/version/1/pdf/render
Alternate Webpage(s)	https://dm5migu4zj3pb.cloudfront.net/manuscripts/70000/70050/cache/70050.1-20150223083241-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/70000/70050/JCI70050.v1.pdf
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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