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Reversible loss of dendritic spines and altered excitability after chronic epilepsy in hippocampal slice cultures.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Müller, Matthias Gähwiler, Beat H. Rietschin, Lotty Thompson, Scott M. |
| Copyright Year | 1993 |
| Abstract | The morphological and functional consequences of epileptic activity were investigated by applying the convulsants bicuculline and/or picrotoxin to mature rat hippocampal slice cultures. After 3 days, some cells in all hippocampal subfields showed signs of degeneration, including swollen somata, vacuolation, and dendritic deformities, whereas others displayed only a massive reduction in the number of their dendritic spines. Intracellular recordings from CA3 pyramidal cells revealed a decrease in the amplitude of evoked excitatory synaptic potentials. gamma-Aminobutyric acid-releasing interneurons and inhibitory synaptic potentials were unaffected. Seven days after withdrawal of convulsants, remaining cells possessed a normal number of dendritic spines, thus demonstrating a considerable capacity for recovery. The pathological changes induced by convulsants are similar to those found in the hippocampi of human epileptics, suggesting that they are a consequence, rather than a cause, of epilepsy. |
| Starting Page | 1 |
| Ending Page | 5 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/90/1/257.full.pdf |
| PubMed reference number | 8093558v1 |
| Volume Number | 90 |
| Issue Number | 1 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bicuculline CA3 field Congenital Abnormality Dendritic Spines Epilepsy Interneurons Picrotoxin Pyramidal Cells Seizures Synaptic Potentials Vertebral column gamma-Aminobutyric Acid |
| Content Type | Text |
| Resource Type | Article |
